Research Associate - Bioinformatics/ Computational Biology Cincinnati Children's Hospital - Cincinnati, OH

简介：  POSITION TITLE: Research Associate-Data/Technology DEPARTMENT: Varies SUPERVISOR'S TITLE: Faculty TITLES SUPERVISED: Research Assistants, Data Analysts, Biostatisticians TOTAL NUMBER OF FTE's DIRECTLY OR INDIRECTLY SUPERVISED: 0-4 PURPOSE OF POSITION: To conduct independent research and support the independent research of others in a Medical Center dedicated to the care of infants, children, and adolescents. A Computational Research Associate position is immediately available in the Weirauch Lab. The Weirauch lab studies the mechanisms of gene transcriptional regulation, and the impact of disease-associated genetic variation on these mechanisms using computational and experimental methods. We are looking for an extremely talented and highly motivated computational researcher (Bioinformatics, Computer Science, etc.) to work on multiple cutting-edge research projects. You will work in a highly collaborative environment at the interface of genetics, immunology, computer science, and immune-mediated disease research. We are currently focused on autoimmune diseases (including but not limited to Systemic Lupus Erythematosus and Multiple Sclerosis). Lab Website: https://www.cincinnatichildrens.org/research/divisions/a/genomics-etiology/labs/weirauch MAJOR DUTIES AND RESPONSIBILITIES:Perform analysis and experiments: Design, execute, and record analysis and experiments; apply standard scientific protocols to research, and improve current methods and evaluate innovative techniques. Develop and implement human subject research protocols, vertebrate animal research protocols and design experimental procedures and documentation in accordance with the relevant laws and regulations. Prepare, clean and analyze data. Maintain optimal protocol and accuracy by conducting regular quality and reproducibility checks. Communicate results/findings: Draft, write, and edit scientific reports, papers, journal articles, and abstracts. Present information on research and department work to others at department meetings, journal clubs, and seminars. Present results and discuss relevant insights with Faculty and provide useful recommendations and analysis. Innovate and advance departmental capabilities: Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current analysis/experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all analysis and experiments. Develop, set-up, and verify new procedures in the department. Standardize and establish new published procedures; evaluate innovative techniques. Develop new protocols; design formats. Maintain an integral role in the department's meetings, presentations, and publications. Troubleshoot and correct erroneous results or problems with department software/equipment. Maintain and repair software/equipment; monitor proper use by personnel. Financial/Budgeting: Assist in preparing grant applications. Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve, and initiate check requests; track funding, maintain accurate balance, and resolve any discrepancies. Staff Leadership: May provide day-to-day functional leadership for a team or directly manage a minimal number of support staff. Establishes team goals. Gives input into, and performs employee performance reviews. Oversees and guides work assignments. Serves as the functional expert and provides guidance to the team. Education and Training: May serve as course master and develop new courses at the undergraduate and graduate level, including appropriate plans for evaluating student performance; may deliver lectures as a guest lecturer in courses organized by other faculty. Assist in the training of new employees. Serve as a resource and/or mentor to coworkers. Assist in the development and presentation of department training. Identify training needs and provide necessary coaching. 

任职资格:Required:Ph.D., MD, or equivalent degree. Three years' related experience.Experience in analysis of high throughput sequencing data (ChIP-Seq, DNase-Seq, and/or ATAC-Seq) is necessary. Critical thinking, the ability to multi-task, and experience in linux are required. Preferred:PhD in Computer Science, Physics, Biomedical Informatics, Bioinformatics, Epidemiology, Biostatistics or other similar quantitative disciplinesExperience in related fieldStrong biological knowledge (especially in gene regulation) is preferred but is not required. REQUIRED SKILLS:Organization: Possess strong organization skills and attention to detail Research Methods Skills: Designing and conducting effective research studies that address measurement, data collection, and validity issues; identifying or developing appropriate, accurate, relevant, and reliable measurement methods; drawing appropriate conclusions from study results. Analysis: Strong analytical skills with the ability to make judgments and recommendations based on statistical analysis Statistics - Intermediate: Familiarity with statistical software, statistical techniques, statistical process control principles, and graphical data display  

Title: Biomarker Trial Manager

Location: NJ

 Large Global Pharmaceutical Company

 Working Hours: 37.50 hrs/week

 Duration: 6 months and have a chance to extend

简介:

 工作职责:

 1. Support individual clinical trial teams (CTTs) and Biomarker Sub-teams as required for all tech-nical and operational biosample-related matters for assigned projects by liaising with internal stakeholders. Assist Study Lead by forecasting the biosample operational costs and reviewing in-voices.

2. Provide input on biomarker and clinical pharmacology sections in clinical trial-related (such as protocols and consents) and regulatory documents (such as INDs, IBs, etc.) under the supervision of the LF representatives.

3. Responsible for all clinical biosample tracking processes, including setting up laboratory proce-dures, tracking clinical biosamples from collection to analysis, and assisting with the relevant data management components.

4. With support, provide input and solutions on the ethical considerations for biosample collection and analysis for protocols and consents to ensure that all specific processes needed for approval in different countries are implemented.

5. With support, establish central and analysis laboratory components for assigned studies. Oversee central labs and analysis labs for clinical, biomarker and PK sample collection kits and sample lo-gistics. Responsible for all of the documentation required to set up central and analysis lab proce-dures

6. Liaise with internal stakeholders, and the CTT to determine analysis labs for biomarkers and other clinical biosamples. Manage relationships with analysis labs and provide input into trial-specific agreements, following the standard process.

7. Define biosample needs for the case report forms (CRFs), in collaboration with LF representatives, Study Lead, trial data manager (TDM) and analysis labs; and for data formatting and data transfer set-up needs for samples. With support, liaise with the trial data manager (TDM) and labs for data transfer and data reconciliation

8. Partner with Global Correlative Science Leader (GCSL), study biostatisticians, and labs to estab-lish biomarker analysis plan; under guidance, review transferred data to ensure quality.

9. Develop, with assistance, training material on the technical aspects of clinical biosample collec-tions for the clinical sites, including study specific lab manuals and additional site and monitor training needs. May also be involved in training of monitors and site personnel.

任职资格:

 At least 2 years of experience handling clinical samples

 Familiarity with biomarker discovery methodologies, assay technologies and molecular biology.

 Basic knowledge of oncology or hematology strongly preferred

 Knowledge of Good Clinical Practice

 Basic knowledge of clinical trial design; understanding of the overall drug development process

 Excellent organizational and communication skills

 Ability to manage multiple competing priorities and meet timelines

 Proven networking skills and ability to share knowledge and experience amongst colleagues.

联系方式： Please feel free to send your resume to lu.cheng@techdataservice.com if you are interested. 

简介：老板不算大牛（不是HHMI ，也不是NAS），也没有奇迹发现，但有些独特的遗传系统。诚聘踏实认真做事，努力享受科研的同事。实验室稳定成熟，中等大小（人数和年龄都比5大，比10小）。DNA修复和血液肿瘤方向。新涉及大数据领域，崭新平台，独有数据。欢迎聪明努力的你和我们一起来发现。位置立即有效。个人信箱，非诚勿扰。谢谢！

联系方式：有兴趣的同学请联系PI，实验室网站https://icg.cpmc.columbia.edu/research-faculty/Shan-Zha-lab

联系方式：Motivated candidates with relevant research experience in lncRNAs, metabolism, and liver are welcome to send their CV, cover letter, and contact information of three references to Dr. Ling Yang, Ph.D., Assistant Professor, at ling.yang@temple.edu. The postdoctoral fellows will learn how lncRNAs and protein-coding genes are coordinated together to regulate glucose and lipid metabolism using both cell culture and mouse models. The postdoctoral fellows will get a lot of hands-on mentoring from the PI and other experts in the related field to help them achieve their goals. After postdoc training, the postdoctoral fellows should be able to develop their own research projects and to apply for grants.

简介：实验室招生物信息学博士后，欢迎感兴趣的各位踊跃报名。

实验室主要从事肾病研究，有1000个人的肾病整合多维组学数据和详细的临床生理病理特征记录。

实验室主页：http://www.med.upenn.edu/susztaklab/

主页已经很多年没有改了。老板已经升为宾夕法尼亚大学的Professor，现在已经升为哈佛的Professor了。目前在费城，九月后全部驻扎哈佛。（波士顿很冷，怕冷慎入）

老板比较注重信息分析，实验室的项目多样，每个人都有自己独立的课题，也有团队合作。团队大小适量15人左右。常年有funding。单细胞rna-seq做得非常好，刚发了一篇新鲜的science。

感兴趣欢迎投简历。

联系方式： https://www.postdocjobs.com/posting/7050687

简介：Two postdoctoral positions are immediately available at Department of Pathology, in Northwestern University Feinberg School of Medicine. The ideal candidates should have a Ph.D. within last three years in cellular and molecular immunology with an emphasis on the T cell biology, autoimmunity or cancer immunology preferred.  The work in Fang Lab focuses on the molecular regulation (in particular the epigenetic and ubiquitin pathways) of T cell immune tolerance, autoimmune disease and cancer  (For more information, JCI, 119(10):3048-58; PNAS, 109(3):899-904 & 113(37):10394-9; EMBO J, 32(18):2477-90; Molecular Cell, 46(4):484-94;  JEM, 211(12): 2467-79;  Nature Communications, 15;7:12073 & in press.). 

The successful applicants must have a proven academic publication track record, including first-authored publications at high profile journals, as well as excellent scientific, organizational, record-keeping, problem-solving skills. US citizenship or permanent residency is required for one position.  

联系方式：Please send a curriculum vitae, a brief cover letter summarizing current research and career goals, and the names and contact information of 2-3 references to: Email: fangd@northwestern.edu  

简介：Post-doctoral position in molecule/cell genomics, at Institut Curie, Paris. We are looking for a motivated and productive post-doctoral fellow with strong bioinformatics and biostatistics skills to join our ATIP-Avenir team Replication Program and Genome Instability at the Institut Curie, Paris, France. The team focuses on using cutting-edge high-throughput genomic approaches and genome-wide data analyses to study the spatio-temporal replication program of the human genome and its impact on genome stability in normal and cancer cells, in population as well as at single molecule/cell level.The Institut Curie, located in the heart of Paris, is the largest French cancer research center and one of the world’s leading institutions in the field. It represents an excellent location to perform multidisciplinary research supported by a strong network of the PSL Research University. The project will be performed in close collaboration between our genome analysis team, the bioinformatics/sequencing platforms and the worldwide experimental biologist experts. The candidate will benefit from an excellent multi-disciplinary environment.

任职资格：Applicant should be a research hold, or in the process of completing, a PhD degree in bioinformatics or related areas. The candidate should have solid programming skills and a strong interest in genome biology. Experience with3th generation sequencing, high-throughput imaging or single cell data analysis is a plus. The candidate should be highly motivated, curious and enthusiastic to work in a collaborative team. Duration: 1-year renewable, up to 3 years.

联系方式： Interested candidates should send a detailed CV (education, work/research experience, language skills and other skills relevant for the position, list of publications) along with a cover letter and contact details of 3 referees to C.L. Chen (chunlong.chen@curie.fr). 

简介：University of North Dakota School of Medicine and heath Science,department of Biomedical Science, Post-Doctoral Fellow.UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES, Department of Biomedical Sciences, Post-Doctoral FellowCompensation and Appointment: $47,000 + (DOE).

Review of applications will begin immediately. Position is open until filled. For more information or to apply visit https://und.edu/finance-operations/human-resources-payroll/careers/secure/job-openings-external.cfm?category=2000+Academic&subcategory=2240+Post+Doctorate+Research+Fellow%3A.

Research interests in mechanisms of chromatin regulation and model organisms. The position is available immediately and is planned for at least three years, with a possibility of renewal. The successful candidate is expected to apply biochemical and molecular biology techniques (molecular cloning, Western blot, qRT-PCR, ChIP, ChIP-seq, protein purification, protein complexes reconstitution in vitro) and microscopy to conduct the research on epigenetic regulation of development and cancer. The primary research focus of Dr. Tulin's lab is on fundamentals of chromatin regulation and RNA fate during the normal development and in carcinogenesis, as well as on translating the findings of fundamental biology for clinical applications in oncology. Projects in Dr. Tulins lab cover the molecular mechanisms of chromatin remodeling and regulation of gene expression and employ in vitro assays as well as mouse and Drosophila model organisms.

最低要求:

Ph.D. in molecular biology, molecular genetics, biochemistry, or a related field.

0 to 3 years of postdoctoral research experience.

Submit a letter of interest specifying your career goals, CV, and names of at least 3 references.

Successful completion of criminal history records check.

Extensive experience in genetics, confocal microscopy, protein purification, live-cell imaging, and genomic/proteomics.

联系方式：To apply, visit https://und.edu/finance-operations/human-resources-payroll/careers/secure/job-openings-external.cfm?category=2000+Academic&subcategory=2240+Post+Doctorate+Research+Fellow%3A.

课题组Principal Investigator郭春君博士2009年本科毕业于复旦大学药学系，2015年在美国南加州大学药学院（The University of Southern California）获得博士学位，师从Clay C.C.Wang教授，随后到美国加州UCSF和Standford 进行博士后训练，在Michael Fischbach 教授课题组从事肠道微生物小分子作用机理的研究。郭春君博士于2018年9月入职美国Cornell University-Weill Cornell Medicine 担任Assitant Professor(Tenure-Track),开展独立研究工作。课题组研究方向为利用基因编辑技术（CRISPR)改造肠道菌群，研究其释放小分子的生物活性及对宿主生理功能的影响。郭春君博士目前已在综合或专业领域内权威期刊（Cell, Nat. Commun, JACS,  PNAS)等发表论文17篇。详细发表情况请看： https://scholar.google.com/citations?user=tY8JGkAAAAAJ&hl=en

招聘类型：博士研究生、博士后、访问学者；

招聘学校：Cornell University-Weill Cornell Medicine;

学校地址：413 E 69th Street, New York, NY 10021;

专业方向：博士申请者需微生物，化学生物学或免疫学相关本科经历；博后及访问学者需微生物基因编辑，（肠道）免疫，或生物信息学背景，有质谱分析相关经验优先；

入职时间：博后及访问学者位置常年开放中；博士研究生，2018年冬季或2019年秋季入学；

热爱科研，具有强烈探索欲，进取心，责任感，及团队合作精神；可以用英文进行简单的交流，并熟练使用英文撰写学术论文。

报名方法：博士后和访问学者请将个人简历，推荐人信息，和研究兴趣简介发送至chunjung19@gmail.com；博士申请者可以直接去学校网站申请并填写郭春君课题组为意向实验室。

We are inviting highly  motivated and creative applicants for  two post-doctoral positions in the laboratory  of Dr.

Chun-Jun (CJ) Guo at Weill Cornell Medicine. Our laboratory is located in the Jill Roberts Institute for Research

in  Inflammatory Bowel  Disease  housed  in  the new  Belfer  Research  Building.  We  apply a  combination  of

bioinformatics,  microbial genetics,  metabolomics,  and chemical  biology  technique to  study  how the  human

microbiota-derived small  molecules  and metabolic  pathways affect  host biology.  We are  interested  in using

genetically engineered bacteria, and germ free and other mouse models to understand the microbe-microbe and

microbe-host interaction at the level of molecular mechanism.

Candidates with  diverse  research background  are welcome  to apply.  A Ph.D.  or equivalent  in Immunology,

Microbiology, Chemical Biology, Bioinformatics, or related field is recommended. We are very excited about the

researchers with technical expertise in two or more of the following: microbial genetics (CRISPR/Cas9), microbial

bioinformatics, GC/LC mass data analysis,  or multi-parameter flow cytometry. Please be noted that  this will be

a co-mentored position by Professor David Artis and me at the JRI. The candidate will also have the opportunity

to  interact  with many  other  great  scientists in  the  TriI  community  (Weill Cornell  Medicine-The  Rockefeller

University-Memorial Sloan Kettering Cancer Center).

If you are interested, please send a cover letter describing your research background, interests, and career goals,

as  well   as  the   names  and   addresses  of   three  references   and  a   CV,  to   Dr.  Chunjun   (CJ)  Guo   at

chunjung19@gmail.com.

简介：德克萨斯大学休斯顿医学中心The University of Texas Health Science Center at Houston (UTHealth) 招生物信息学方向Research assistant professor(研究助理教授)年薪8万美元以上(可能更高)以及 faculty associate，年薪6.5-9.5万美元。

详情请见：https://www.nature.com/naturejobs/science/jobs/642783-research-assistant-professor-and-faculty-associate-positions-in-the-center-for-precision-health-uthealth-school-of-biomedical-informatics

另一个岗位是生物信息学的postdoc职位（没有在上面链接里提到，但是也招！），偏向计算机，方向是NLP (自然语言处理)。

简介：Research Fellow Job Numbers: 94248 &95819. Two postdoctoral Research Fellow positions are open in the Brain Tumor Center for individuals with an interest in glial cell biology, brain cancers, and neurodegenerative diseases.  Research areas include brain development and tumorigenesis, demyelinating diseases such as multiple sclerosis, and functional regeneration (http://www.cincinnatichildrens.org/bio/l/qing-richard-lu/). 

任职资格：Recent PhD or MD graduates with a strong background in one or more of the following areas: molecular & cell biology, neurobiology, cancer biology, or computational biology are encouraged to apply.

联系方式：Contact: Qing (Richard) Lu, PhD         Email Address: Richard.Lu@cchmc.org

简介：We are looking to hire a talented postdotoral scientist who has a passion for genomics and the study of human disease.This scientist will lead the application and developement of computational methods to multiple ongoing studies of rare human disorders that each leverage the power of family genetics.We are committed to building a diverse laboratory and we strongly encourage applications from female and minority candidateds.If interested,please email Araon Quinlan and apply here by providing your CV,two letters of recommendation,and a statement of articulating your postdoctoral and future career goals.

联系方式：http://quinlanlab.org/

I ran across your resume today while searching for recent PhD Statistics graduates that would be looking for an awesome opportunity in the Chicago area.

简介：Provide statistical consulting and computing support for projects in drug discovery (CRISPR/Cas9 functional genomic screen, Phenotypic screening, etc.), pre-clinical and clinical biomarker research (genomics, imaging, etc.), and for biomarker, PK and immunogenicity assays used in preclinical and clinical studies. Primary focus will be on projects related to target identification, personalized medicine, subgroup identification, and biomarker/genomics research (pre-clinical to late-phase clinical trials). 

工作职责: Statistical collaborations and consultations on some or all of the following applications: Target Identification ,Personalized medicine, Subgroup identification, In-Vitro and In-Vivo pharmacology assays, Genomics (CRISPR/Cas9 functional genomic screen, high throughput gene expression arrays, CGH arrays, next generation sequencing, microRNA, etc.), Proteomics, Imaging, and other biomarker data generated from pre-clinical and clinical studies, Design of biomarker-based clinical trials for personalized therapies, and general methodological research on related topics. 

Development of novel functional genomic screening hit selection algorithms. Integration of CRISPR screening data with other genomics data (expression profiling, genotype, etc.). Perform Gene network/pathway analysis and visualization 

Develop and maintain good working relationships with statisticians, clinical and discovery scientists, and personnel from other areas within the company and also with scientists from external institutions when communicating/collaborating on various projects. 

Maintain and develop further expertise in the use of R, SAS, UNIX utilities, JAVA, Perl, JMP, VB and other programs, and continue development of such utilities/macros to improve process flow, as well as maintaining appropriate documentation. 

Consult/collaborate with other statisticians on various statistical methodologies and statistical computing applications. Evaluation and implementation of advanced statistical models. Proactively seek input and review from other experts within and outside the group on various projects and research activities, and share technical information when appropriate. 

Propose opportunities for productivity improvements and implementation plans. 

任职资格：

Ph.D. in Statistics, Biostatistics, or a highly related field, with some applied consulting or research experience on topics related to pharmaceutical research, bioinformatics, target identification, biomarkers, and subgroup identification. 

0 - 1 years of related experience with demonstrated skills/accomplishments. 

Expertise in statistical methodologies such as predictive modeling, machine learning methods, nonlinear regression, mixed effects models, multivariate analysis, robust statistics, adaptive designs, etc. 

Familiarity with NGS-based pooled CRISPR screening data 

Relevant academic/industry experience on topics related to bioinformatics, genomics, clinical biomarker studies, personalized medicine, and other applications mentioned above. 

Strong computing skills in R, SAS and other programming languages. 

Good grasp of clinical, biochemistry, molecular biology, and related subjects.

联系方式：Andrea Moralez，Sr. Recruiter，National SAS Business， Analytics & Clinical Practice

T: +1 269 553 5150

F: +1 269 553 5198

andrea.moralez@experis.com 

欢迎点击以下链接，关注前三期的微offer海外科研招聘信息汇总（惊喜不断哦！）

[海外科研招聘]罗切斯特理工大学，斯坦福大学，纽约州立大学，奥古斯塔州立大学，德克萨斯大学等你来！（20180520）

[海外科研招聘]哥伦比亚大学，Broad 研究所，密歇根大学，ORAU, Promega Corporation等你来!(20180518)