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生物信息的最高境界是什么，
是无招胜有招，还是人机合一
其实都不是，问一个做生信的高手，他会告诉你，生信的最高境界
是能手动，绝不编程。
每年核酸研究、生物信息等期刊都会盘点最新的网红级生物信息数据库和工具。这些工具往往涉及的都是最新的热点，也就是说往往你需要大篇幅编程的分析或者作图，在这些网上上，点点点，就搞定了。
速速收藏
The 2018 Nucleic Acids Research database issue and the online molecular biology database collection
| Descriptions of new online databases in the 2018 NAR Database issue | ||
| Database | URL | Brief descriptiona |
| 3DIV | http://kobic.kr/3div | 3D-genome Interaction Viewer and database |
| AAgMarker | http://bioinfo.wilmer.jhu.edu/AAgMarker/index.jsp | Serum autoantigen biomarkers from proteome microarrays |
| aBiofilm | http://bioinfo.imtech.res.in/manojk/abiofilm/ | Anti-biofilm compounds |
| ActiveDriverDB | https://activedriverdb.org/ | Genome variation mapped against post-translational modifications |
| ADReCS-Target | http://bioinf.xmu.edu.cn/ADReCS-Target | Adverse Drug Reactions linked to proteins, genes and genetic variants |
| AmyPro | http://amypro.net | Proteins with validated amyloidogenic regions |
| anti-CRISPRdb | http://cefg.uestc.edu.cn/anti-CRISPRdb/ | anti-CRISPR proteins |
| AraGWAS Catalog | https://aragwas.1001genomes.org | Arabidopsis Genome-Wide Association Studies |
| ASpedia | http://combio.snu.ac.kr/aspedia | Alternative Splicing Encylopedia |
| ChannelsDB | http://ncbr.muni.cz/ChannelsDB | Channels, pores and tunnels found in biomacromolecular structures |
| CirGRDB | http://cirgrdb.biols.ac.cn | Regulation of RNAs in circadian rhythms |
| ClusterCAD | https://clustercad.jbei.org and http://clustercad.igb.uci.edu | Engineering of type I modular polyketide synthases |
| CR2Cancer | http://cis.hku.hk/CR2Cancer | Chromatin Regulators and Cancer |
| CSCD | http://gb.whu.edu.cn/CSCD | Cancer-Specific cRNA Database |
| dbCAN-seq | http://cys.bios.niu.edu/dbCAN_seq | Genome scale CAZymes and CAZyme gene clusters |
| dbCoRC | http://dbcorc.cam-su.org/ | Core transcriptional Regulatory Circuit models |
| DifferentialNET | http://netbio.bgu.ac.il/diffnet | Differential protein-protein interactions in human tissues |
| DiseaseEnhancer | http://biocc.hrbmu.edu.cn/DiseaseEnhancer/ | Enhancer-disease associations |
| DISNOR | http://disnor.uniroma2.it/ | Protein interaction networks linking disease genes |
| DreamBASE | http://rna.sysu.edu.cn/dreamBase | Human expressed pseudogenes: DNA Modification, RNA Regulation and bound proteins |
| ECOdrug | http://www.ecodrug.org | Evolutionary COnservation of Drug targets |
| EpiDenovo | http://61.148.58.210:8080/EpiDenovo/ | The epigenome in mammalian embryonic development |
| EPD | https://peptracker.com/epd/ | Encyclopedia of Protein Dynamics |
| EVLncRNAs | http://biophy.dzu.edu.cn/EVLncRNAs/ | Experimentally Validated lncRNAs including disease indications |
| eRAM | http://www.unimd.org/eram/ | Annotated rare diseases |
| ExoRBase | http://www.exoRBase.org | Human blood exosome RNAs |
| FlavorDB | http://cosylab.iiitd.edu.in/flavordb | Flavour molecules |
| FusionDB | http://services.bromberglab.org/fusiondb/ | Functional-repertoire similarity-based organism network |
| GVM | http://bigd.big.ac.cn/gvm/ | Genome Variation Map |
| HCMDB | http://hcmdb.i-sanger.com/index | Human Cancer Metastasis DataBase |
| HEDD | http://zdzlab.einstein.yu.edu/1/hedd.php | Human Enhancer Disease Database |
| ICG | http://icg.big.ac.cn | Internal Control Genes for RT-qPCR normalization |
| IMOTA | https://ccb-web.cs.uni-saarland.de/imota/ | Interactive Multi-Omics-Tissue Atlas |
| iPTMnet | http://research.bioinformatics.udel.edu/iptmnet/ | Post-Translational Modification networks |
| ITSoneDB | http://itsonedb.cloud.ba.infn.it/ | Eukaryotic ribosomal RNA Internal Transcribed Spacer 1 sequences |
| jMorp | https://jmorp.megabank.tohoku.ac.jp/ | Metabolomics and proteomics of 1000 healthy Japanese people |
| LINCS Data Portal | http://lincsportal.ccs.miami.edu/dcic-portal/ | Cell-based perturbation-response signatures |
| LinkedOmics | http://www.linkedomics.org | Multi-omics analysis of 32 cancers |
| Lnc2Meth | http://www.bio-bigdata.com/Lnc2Meth | lncRNAs and DNA methylation |
| m6AVar | http://m6avar.renlab.org/ | Human variants affecting m6A sites |
| MeDReaders | http://medreader.org/ | Transcription factors binding methylated DNA |
| microbiomeDB | http://microbiomeDB.org | Mining and analysing microbiome data |
| MINTbase | https://cm.jefferson.edu/MINTbase/ | Mitochondrial and nuclear tRNA fragments |
| miRCarta | https://mircarta.cs.uni-saarland.de/ | miRNAs and precursors |
| mirTrans | http://mcube.nju.edu.cn/jwang/lab/soft/mirtrans/ | Cell-specific transcriptional information for human miRNAs |
| MIST | http://fgrtools.hms.harvard.edu/ProteinSearch/ | Model organism molecular interaction data |
| MGA | http://ccg.vital-it.ch/mga/ | Mass Genome Annotation |
| MMP | https://mmp.sfb.uit.no/databases/ | Marine Metagenomics Portal |
| MSDD | http://www.bio-bigdata.com/msdd/ | miRNA SNP Disease Database |
| mSignatureDB | http://tardis.cgu.edu.tw/msignaturedb | Mutational signatures in human cancers |
| MVP | http://mvp.medgenius.info | Microbe-phage interactions |
| NPASS | http://bidd2.nus.edu.sg/NPASS/ | Natural Product quantitative Activities |
| OverGeneDB | http://overgenedb.amu.edu.pl | Overlapping protein-coding genes |
| PAMDB | http://pseudomonas.umaryland.edu | Pseudomonas aeruginosaMetabolome DataBase |
| PancanQTL | http://bioinfo.life.hust.edu.cn/PancanQTL/ | Expression quantitative loci (eQTL) analysis of cancer samples |
| PedAM | http://www.unimd.org/pedam/ | Pediatric Disease Annotation & Medicine |
| PCSD | http://systemsbiology.cau.edu.cn/chromstates | Plant Chromatin State Database |
| PGG.Population | https://www.pggpopulation.org | Genomic diversity of diverse human populations |
| PharmacoDB | http://pharmacodb.pmgenomics.ca | Pharmacogenomics of cancer cell lines |
| PICKLES | http://pickles.hart-lab.org | Pooled In-vitro Crispr Knockout Library Essentiality Screens |
| PIT-DB | http://pitdb.org | Proteomics Informed by Transcriptomics |
| Planteome | http://www.planteome.org | Portal for plant ontologies and annotations |
| PopHuman | http://pophuman.uab.cat | Population genomics-oriented genome browser |
| qPrimerDB | http://biodb.swu.edu.cn/qprimerdb | qPCR primers for 200 organisms |
| RISE | http://rise.zhanglab.net | RNA-RNA interactions |
| RNArchitecture | http://iimcb.genesilico.pl/RNArchitecture/ | Structural classification of RNAs |
| SBCCDB | http://sbcddb.moffitt.org | Sleeping Beauty Cancer Driver DataBase |
| SCPortalen | http://single-cell.clst.riken.jp/ | Human and mouse single-cell centric database |
| SEECancer | http://biocc.hrbmu.edu.cn/SEECancer | Evolutionary-stage specific somatic events in cancer |
| StemMapper | http://stemmapper.sysbiolab.eu | Stem cell gene expression |
| STCRDab | http://opig.stats.ox.ac.uk/webapps/stcrdab | Structural T-Cell Receptor Database |
| SysteMHC Atlas | https://systemhcatlas.org/ | Immunopeptidomics of MHC-bound peptides |
| Tabloid Proteome | http://iomics.ugent.be/tabloidproteome | Protein associations inferred from Mass Spectrometry |
| Target-Pathogen | http://target.sbg.qb.fcen.uba.ar/patho | Drug target optimisation in pathogens |
| TC3A | http://tc3a.org/ | 3΄ untranslated regions, alternative polyadenylation and cancer |
| TissGDB | http://zhaobioinfo.org/TissGDB | Tissue-specific Gene DataBase in cancer |
| TranslatomeDB | http://www.translatomedb.net/ | Translatome data from RNC-Seq and Ribo-Seq |
| TriForC database | http://bioinformatics.psb.ugent.be/triforc/ | Triterpene pathways |
| TCSBN | http://inetmodels.com | Tissue and Cancer-Specific Biological Networks |
| VarCards | http://varcards.biols.ac.cn/ | Interpretation of coding variants in the human genome |
| VDJdb | https://vdjdb.cdr3.net/. | T-cell receptor sequences with known antigen specificity |
| Virus Taxonomy | http://ictv.global | Taxonomy of viruses |
| Updated descriptions of databases most recently published elsewhere | ||
| Database | URL | Brief descriptiona |
| BioMuta and BioExpress | https://hive.biochemistry.gwu.edu/biomuta and https://hive.biochemistry.gwu.edu/bioxpress | Cancer SNVs and gene expression |
| BioStudies | https://www.ebi.ac.uk/biostudies/ | Data of all kinds relating to a single study |
| iSyTE | http://research.bioinformatics.udel.edu/iSyTE | integrated Systems Tool for Eye gene discovery |
| miRandola | http://mirandola.iit.cnr.it/ | Extracellular and circulating non-coding RNAs |
| mirDIP | http://ophid.utoronto.ca/mirDIP/ | microRNA Data Integration Portal |
| MNDR | http://www.rna-society.org/mndr/ | Mammal ncRNA-Disease Repository |
| NLSdb | https://rostlab.org/services/nlsdb/ | Nuclear Localization Signals |
| PAGER 2.0 | http://discovery.informatics.uab.edu/PAGER/ | Pathway, Annotated-list, and Gene-signature Electronic Repository |
| ProteomicsDB | https://www.ProteomicsDB.org | Mass spectrometry of the human proteome |
| PULDB | http://www.cazy.org/PULDB_new/ | Polysaccharide Utilization Loci in Bacteroidetes species |
| ReMap | http://remap.cisreg.eu | Transcription factor ChIP-seq data |
| RMDB | http://rmdb.stanford.edu | Structure mapping of RNA |
| SuperDrug2 | http://cheminfo.charite.de/superdrug2 | Approved drugs |
| TRRUST v2 | http://www.grnpedia.org/trrust/ | Transcriptional regulatory interactions in human and mouse. |
| TumorFusions | http://www.tumorfusions.org | Tumour fusion genes |
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